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Article – Journal of Advanced Chemical Sciences

Journal of Advanced Chemical Sciences, Volume 2,Issue 4,2016 Pages 369-372

Simultaneous Electrochemical Determination of Paracetamol and Ibuprofen at The Glassy Carbon Electrode
E. Suresh, K. Sundaram, B. Kavitha, S. Maria Rayappan, N. Senthil Kumar*

The aim of this investigation is to develop an analytical method for the simultaneous estimation of Paracetamol and ibuprofen in commercial tablets using differential pulse stripping voltammetric (DPSV) and square wave stripping voltammetric (SWSV) techniques. The effect of supporting electrolyte, pH and scan rate on voltammetric response of paracetamol with ibuprofen was studied and the optimum experimental conditions were derived. Linear response of peak currents on the concentration in the range between 300 and 700 ppb, good repeatability (RSD of 2.4% for SWSV and 2.7% for DPSV of seven successive measurements) and the detection limit of 200 ppb for DPSV and 100 ppb for SWSV were observed. The method was validated for accuracy, precision and specificity. The practical analytical utility of proposed method was successfully demonstrated by determination of both drugs in pharmaceutical formulations (tablets) with results in a close statistical agreement to those declared by manufactures.

Keywords: Paracetamol; Ibuprofen; Voltammetry; Simultaneous Detection; Pharmaceutical;