Crinum jagus is used in Cameroon western and eastern regions folk medicine in detoxification, the management of diabetes and obesity and also as antivenomous and antipoison. The aim of this work was to evaluate the subchronic toxicity of Crinum jagus extracts on male and female Wistar rats. Subchronic toxicity of aqueous and hydroéthanolic Crinum jagus extracts was determined on two month old normal Wistar rats. Those rats, once daily orally received, hydroethanolic (75, 150 mg/kg b.w.) and aqueous (150 mg/kg b.w.) extracts, during 90 days (tree month). In both males and females animals, the C. jagus effects were investigated on the evolution of weight, food and water intakes, kidney and liver functioning markers (serum total cholesterol (TC), total proteins, creatinine and transaminase: AST and ALT). Both aqueous and hydroethanolic extracts in males as in females, did not cause any adverse changes in anthropometric (body mass, relative weight of liver and kidneys, food and water intakes) and seric parameters (total cholesterol, total proteins, creatinine AST and ALT activity). Instead, those extracts remarkably improved antropometric parameters, liver and kidney function and even protect again atherosclerosis. The results indicated that aqueous and hydroethanolic extracts of Crinum jagus did not induce toxic effect at the doses used in long term treatment; thus justifying its empiric use in detoxification and as antivenomous.

Keywords: Crinum jagus; Subchronic Toxicity; Anthropometric Parameters; Wistar Rats;