This study was carried out to investigate the possible toxic effects of the water extract from Khaya grandifoliola stem bark in Wistar rats. The acute assay used 9 females distributed into 3 groups of 3 rats each. A control group received distilled water and the two test groups received by oral gavage a unique dose of the extract at 2000 mg/kg. In subacute assay, 60 rats both sexes were distributed into 6 groups of 10 rats each (5 males and 5 females) and received the extract by oral gavage for 28 days consecutively. The tests groups received extract at 250, 500 and 1000 mg/kg. The controls and satellite test groups received respectively distilled water and extract at the dose of 1000 mg/kg. Some anthropometrical, hematological and biochemical parameters were measured and histological sections of some organs were realized. LD50 was superior at 2000 mg/kg in acute assay. In subacute toxicity assay, Khaya grandifoliola stimulated the haematopoetic and immune function, showed a significant decrease of alanine transaminase, aspartate transaminase and hypocholesterolaemic effects. Histopathology showed the presence of disturbances at the dose of 1000 mg/kg especially. K. grandifoliola stem bark could possess moderate toxicity at high doses and adequate caution should be exercised in its use in ethnomedicine.

Keywords: Khaya grandifoliola; Acute Toxicity; Subacute Toxicity; Wistar Rats;