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Article – Journal of Pharmaceutical and Medicinal Research

Journal of Pharmaceutical and Medicinal Research, Volume 5,Issue 1,2020 Pages 87-88


Assessment of the Likelihood of a Radiation-Induced Abortion in the Unintentional Irradiation of a Live Human Fetus
Eduardo Galiano*, Marcelo Godin

https://doi.org/10.30799/jpmr.045.20050101

This work is licensed under a Creative Commons Attribution 4.0 International License

The purpose of this work was to calculate the dose accidentally absorbed by a live fetus during a diagnostic CT procedure on a pregnant patient, and to then assess the likelihood that the premature termination of the pregnancy was radiation-induced. A patient underwent a diagnostic CT procedure as part of her initial clinical workup for a stage II cervical cancer. At the time of imaging - and unbeknownst to the staff - the patient was found to be 12 weeks pregnant. Approximately two weeks later, the fetus became non-viable and was surgically removed. Following established institutional procedures, the case was referred to the physics department for further dosimetric evaluation to determine what role - if any - the fetal dose played in the premature termination of the pregnancy. The fetal dose was determined using Wagner’s CTDI Phantom Dose Reference Model method. A slice thickness of 6 mm and a CTDIvol of 1.13 mGy were used in our calculations, as suggested in the Abdomen Baby manufacturer’s protocol. As suggested by Wagner, KVp, mAs, and slice thickness corrections were applied to the CTDIvol. With these parameters, our estimated absorbed dose to the fetus was 19.3 mGy. Further, we estimate that the rotation of the fetus through an angle of approximately 90° along the caudo-cephalic axis during imaging, had no clinically relevant effect on the calculated absorbed dose. The fetal dose was well below the consensus levels for negligible risk (50–150 mGy), and the “actionable” level of 150 mGy. At the time of exposure, the fetus was developmentally beyond the critically radiosensitive phase of organogenesis. We conclude that the premature termination of this pregnancy is not likely to be of radiological etiology.



Keywords: CTDI; Fetal Dose; Radiation-Induced Abortion; Organogenesis;

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Journal of Pharmaceutical and
Medicinal Research