The antioxidative potential of Mucuna sanjappae seed was evaluated through in vitro assays. The antioxidant activity of water extract in combination with three different in vitro assays viz., 2, 2- diphenyl- 1- picrylhydrazyl (DPPH), N, N-dimethyl-p-phenylendiamine (DMPD) radical scavenging and ferric-reducing antioxidant power (FRAP) assay was evaluated. The total polyphenol contents (TPC) and total flavonoids content (TFC) were also determined. Tannic acid, gallic acid, p-hydroxybenzoic acid and p-coumeric acid were successfully quantified using RP-HPLC-DAD. The strong antioxidant activity of M. sanjappae may provide a platform for future drug discoveries and novel treatment strategies in oxidative stress related diseases like Parkinson’s disease (PD).

Keywords: Antioxidant; Mucuna sanjappae; Oxidative Stress; Parkinson’s Disease;