The freshwater crab Paratelphusa jacquemontii is a vital component of aquatic ecosystems in South Asia, particularly in India, Sri Lanka, and Bangladesh. While it plays a key role in nutrient cycling and serves as a food source, concerns have emerged regarding its potential toxicity due to bioaccumulation of environmental pollutants. The accumulation of heavy metals (Cd, Pb, and Hg) and pesticide residues in crab tissues (muscle, gills, and hepatopancreas) obtained from contaminated and reference sites is assessed in this work. The findings showed that crabs from industrial areas had far higher concentrations of Pb and Cd. Hepatopancreas > gills > muscle was the order of tissue-specific accumulation. Seasonal differences showed that pesticide residues were higher during the monsoon season. These results point to possible health and ecological dangers connected to eating infected crabs. The study emphasizes the necessity of ongoing observation and better environmental management techniques.