The five Schiff bases hybrid have been synthesized from 2-aminothiazole and pyrazole-4-carboxaldehyde under basic condition. The structure of novel compounds were established on the basis of their elemental analyses IR, ¹H NMR and ¹³C NMR, and then screened for their in vitro antimicrobial activity. Among them 3b and 3d showed excellent activity when compared to other derivatives. Other remaining derivatives showed moderate activity.
Keywords: 2-Aminothiazole; Pyrazole-4-Carboxaldehyde; Schiff Base Hybrid;