A proficient synthesis of 1,3-disubstituted ureas from biuret and different amines has been developed using Montmorillonite K-10 as catalyst under solvent free condition using microwave irradiations. The prominent feature of this protocol includes higher yields, shorter reaction times and cleaner procedure with non-toxic and readily available catalyst. Structural confirmation of the products was done on the basis of spectral data- IR, 1H NMR and melting points comparison with the authentic samples.