A clean protocol for effective and rapid deoximation of aldoximes and ketoximes to the corresponding aldehydes and ketones has been developed using ZrOCl2.8H2O with NaNO2 as catalytic system, under solvent free conditions using microwave irradiations. The modus adopted is mild, selective and is pertinent for both aldoximes and ketoximes substituted with diverse electron withdrawing and donating groups. Oximes of some steroidal compounds have also been deoximated under similar conditions.
Structural confirmation of all the products were done on the basis of spectroscopic analyses-1H NMR and FT-IR and by comparison of their melting point/boiling point with those of authentic samples.
Aldoximes; Ketoximes; Deoximation; Zirconium Oxychloride Octahydrate;
