In present study the water samples were collected from various sites of Godavari and Krishna River. The water samples were extracted by HNO₃-HCL mixture and extracted mass was analyzed for Heavy metals concentration by using ICP-AES technique. The water samples were extracted by using CH₂Cl₂ Solvent and extracted mass was analyzed for different functional group by FTIR and organic compounds by GC-MS technique. The heavy metals and organic compounds in river water adversely affect the water quality and human health.